Gynecomastia with pseudoangiomatous hyperplasia and multinucleated giant cells in a patient without neurofibromatosis.

Dear Editor: Pseudoangiomatous stromal hyperplasia (PASH) and stromal multinucleated giant cells (MGC) can occur in both female and male breast (1-5). In males, simultaneous occurrence of PASH and MGC in gynecomastia was described in patients with neurofibromatosis type 1 (NF-1) (6-8). However, the specificity of this finding for NF-1 still remains unclear because the number of described cases is limited. In male patients without NF-1, PASH with MGC in gynecomastia was not reported, to my knowledge. Here, I would like to describe one such case briefly. A 22-year-old male presented with two years slowly growing unilateral gynecomastia of the right breast. Otherwise, his medical history was unremarkable. The lesion was excised and